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Prenatal Drug Exposures Sensitize Noradrenergic Circuits to Subsequent Disruption by Chlorpyrifos

We examined whether nicotine or dexamethasone, common prenatal drug exposures, sensitize the developing brain to chlorpyrifos. We gave nicotine to pregnant rats throughout gestation at a dose (3 mg/kg/day) producing plasma levels typical of smokers; offspring were then given chlorpyrifos on postnata...

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Publicat a:Toxicology
Autors principals: Slotkin, Theodore A., Skavicus, Samantha, Seidler, Frederic J.
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4658258/
https://ncbi.nlm.nih.gov/pubmed/26419632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tox.2015.09.005
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