The Synthetic Antimicrobial Peptide 19-2.5 Interacts with Heparanase and Heparan Sulfate in Murine and Human Sepsis

Heparanase is an endo-β-glucuronidase that cleaves heparan sulfate side chains from their proteoglycans. Thereby, heparanase liberates highly potent circulating heparan sulfate-fragments (HS-fragments) and triggers the fatal and excessive inflammatory response in sepsis. As a potential anti-inflamma...

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Udgivet i:PLoS One
Main Authors: Martin, Lukas, De Santis, Rebecca, Koczera, Patrick, Simons, Nadine, Haase, Hajo, Heinbockel, Lena, Brandenburg, Klaus, Marx, Gernot, Schuerholz, Tobias
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4658182/
https://ncbi.nlm.nih.gov/pubmed/26600070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0143583
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