Regorafenib: Antitumor Activity upon Mono and Combination Therapy in Preclinical Pediatric Malignancy Models

The multikinase inhibitor regorafenib (BAY 73–4506) exerts both anti-angiogenic and anti-tumorigenic activity in adult solid malignancies mainly advanced colorectal cancer and gastrointestinal stromal tumors. We intended to explore preclinically the potential of regorafenib against solid pediatric m...

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Udgivet i:PLoS One
Main Authors: Daudigeos-Dubus, Estelle, Le Dret, Ludivine, Lanvers-Kaminsky, Claudia, Bawa, Olivia, Opolon, Paule, Vievard, Albane, Villa, Irène, Pagès, Mélanie, Bosq, Jacques, Vassal, Gilles, Zopf, Dieter, Geoerger, Birgit
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4658168/
https://ncbi.nlm.nih.gov/pubmed/26599335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0142612
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