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Mitochondrial ROS in cancer: initiators, amplifiers or an Achilles’ heel?

Mitochondria cooperate with their host cells by contributing to bioenergetics, metabolism, biosynthesis, and cell death or survival functions. Reactive oxygen species (ROS) generated by mitochondria participate in stress signalling in normal cells but also contribute to the initiation of nuclear or...

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Bibliographic Details
Published in:Nat Rev Cancer
Main Authors: Sabharwal, Simran S., Schumacker, Paul T.
Format: Artigo
Language:Inglês
Published: 2014
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4657553/
https://ncbi.nlm.nih.gov/pubmed/25342630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrc3803
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