Disturbed Flow Induces Autophagy, but Impairs Autophagic Flux to Perturb Mitochondrial Homeostasis

Aim: Temporal and spatial variations in shear stress are intimately linked with vascular metabolic effects. Autophagy is tightly regulated in intracellular bulk degradation/recycling system for maintaining cellular homeostasis. We postulated that disturbed flow modulates autophagy with an implicatio...

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Vydáno v:Antioxid Redox Signal
Hlavní autoři: Li, Rongsong, Jen, Nelson, Wu, Lan, Lee, Juhyun, Fang, Karen, Quigley, Katherine, Lee, Katherine, Wang, Sky, Zhou, Bill, Vergnes, Laurent, Chen, Yun-Ru, Li, Zhaoping, Reue, Karen, Ann, David K., Hsiai, Tzung K.
Médium: Artigo
Jazyk:Inglês
Vydáno: Mary Ann Liebert, Inc. 2015
Témata:
Original Research Communications
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4657520/
https://ncbi.nlm.nih.gov/pubmed/26120766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2014.5896
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