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Folic Acid Promotes Recycling of Tetrahydrobiopterin and Protects Against Hypoxia-Induced Pulmonary Hypertension by Recoupling Endothelial Nitric Oxide Synthase
Aims: Nitric oxide (NO) derived from endothelial NO synthase (eNOS) has been implicated in the adaptive response to hypoxia. An imbalance between 5,6,7,8-tetrahydrobiopterin (BH(4)) and 7,8-dihydrobiopterin (BH(2)) can result in eNOS uncoupling and the generation of superoxide instead of NO. Dihydro...
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| Pubblicato in: | Antioxid Redox Signal |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Mary Ann Liebert, Inc.
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4657514/ https://ncbi.nlm.nih.gov/pubmed/26414244 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2015.6329 |
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