PAK4 promotes kinase-independent stabilization of RhoU to modulate cell adhesion

P21-activated kinase 4 (PAK4) is a Cdc42 effector protein thought to regulate cell adhesion disassembly in a kinase-dependent manner. We found that PAK4 expression is significantly higher in high-grade human breast cancer patient samples, whereas depletion of PAK4 modifies cell adhesion dynamics of...

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Detalhes bibliográficos
Publicado no:J Cell Biol
Main Authors: Dart, Anna E., Box, Gary M., Court, William, Gale, Madeline E., Brown, John P., Pinder, Sarah E., Eccles, Suzanne A., Wells, Claire M.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2015
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Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4657161/
https://ncbi.nlm.nih.gov/pubmed/26598620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201501072
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