PRL-3 activates mTORC1 in Cancer Progression

PRL-3, a metastasis-associated phosphatase, is known to exert its oncogenic functions through activation of PI3K/Akt, which is a key regulator of the rapamycin-sensitive mTOR complex 1 (mTORC1), but a coherent link between PRL-3 and activation of mTOR has not yet been formally demonstrated. We repor...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Ye, Zu, Al-aidaroos, Abdul Qader Omer, Park, Jung Eun, Yuen, Hiu Fung, Zhang, Shu Dong, Gupta, Abhishek, Lin, Youbin, Shen, Han-Ming, Zeng, Qi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4657013/
https://ncbi.nlm.nih.gov/pubmed/26597054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep17046
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