Targeted next-generation sequencing of cancer genes identified frequent TP53 and ATRX mutations in leiomyosarcoma

Leiomyosarcoma is an aggressive soft tissue sarcoma with poor patient survival. The genetic changes of leiomyosarcoma remain to be discovered. In this study, we analyzed the genetic changes of 44 cancer-related genes by using next-generation sequencing in 54 leiomyosarcomas. We identified TP53 mutat...

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Vydáno v:Am J Transl Res
Hlavní autoři: Yang, Ching-Yao, Liau, Jau-Yu, Huang, Wei-Ju, Chang, Yu-Ting, Chang, Ming-Chu, Lee, Jen-Chieh, Tsai, Jia-Huei, Su, Yi-Ning, Hung, Chia-Cheng, Jeng, Yung-Ming
Médium: Artigo
Jazyk:Inglês
Vydáno: e-Century Publishing Corporation 2015
Témata:
Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4656784/
https://ncbi.nlm.nih.gov/pubmed/26692951
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