Heat shock protein 90 inhibition by 17-Dimethylaminoethylamino-17-demethoxygeldanamycin protects blood-brain barrier integrity in cerebral ischemic stroke

Metalloproteinase (MMP)9 plays a pivotal role in ischemic stroke induced blood brain barrier (BBB) disruption. Correlation between HSP90 and MMP9 in several diseases prompted us to evaluate the efficacy of HSP90 inhibition as a novel approach to protect BBB integrity in ischemic stroke. ELISA was us...

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Enregistré dans:
Détails bibliographiques
Publié dans:Am J Transl Res
Auteurs principaux: Qi, Jia, Liu, Yan, Yang, Ping, Chen, Ting, Liu, Xin Zhu, Yin, You, Zhang, Jian, Wang, Feng
Format: Artigo
Langue:Inglês
Publié: e-Century Publishing Corporation 2015
Sujets:
Original Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4656760/
https://ncbi.nlm.nih.gov/pubmed/26692927
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