Inhibition of human telomerase in MKN-45 cell line by antisense hTR expression vector induces cell apoptosis and growth arrest

AIM: To investigate the effects of antisense human telomerase RNA (hTR) on the biologic behavior of human gastric cancer cell line: MKN-45 by gene transfection and its potential role in the gene therapy of gastric cancer. METHODS: The hTR cDNA fragment was cloned from MKN-45 through RT-PCR and subcl...

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Publicado en:World J Gastroenterol
Autores principales: Feng, Run-Hua, Zhu, Zheng-Gang, Li, Jian-Fang, Liu, Bin-Ya, Yan, Min, Yin, Hao-Ran, Lin, Yan-Zhen
Formato: Artigo
Lenguaje:Inglês
Publicado: Baishideng Publishing Group Inc 2002
Materias:
Gastric Cancer
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4656416/
https://ncbi.nlm.nih.gov/pubmed/12046065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3748/wjg.v8.i3.436
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