Novel 24-h ovine model of brain death to study the profile of the endothelin axis during cardiopulmonary injury

BACKGROUND: Upregulation of the endothelin axis has been observed in pulmonary tissue after brain death, contributing to primary graft dysfunction and ischaemia reperfusion injury. The current study aimed to develop a novel, 24-h, clinically relevant, ovine model of brain death to investigate the pr...

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Veröffentlicht in:Intensive Care Med Exp
Hauptverfasser: Watts, Ryan P., Bilska, Izabela, Diab, Sara, Dunster, Kimble R., Bulmer, Andrew C., Barnett, Adrian G., Fraser, John F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer International Publishing 2015
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4656265/
https://ncbi.nlm.nih.gov/pubmed/26596583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40635-015-0067-9
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