In vitro and in vivo functional characterization of bovine vitamin K-dependent gamma-carboxylase expressed in Chinese hamster ovary cells.

Coagulation factor IX is a serine protease for which high-level expression of biologically active protein in heterologous cells is limited due to inefficient proteolytic removal of the propeptide as well as vitamin K-dependent carboxylation of multiple amino-terminal glutamic acid residues. We have...

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Библиографические подробности
Главные авторы: Rehemtulla, A, Roth, D A, Wasley, L C, Kuliopulos, A, Walsh, C T, Furie, B, Furie, B C, Kaufman, R J
Формат: Artigo
Язык:Inglês
Опубликовано: 1993
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC46562/
https://ncbi.nlm.nih.gov/pubmed/8506307
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