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Angiotensin II Downregulates MicroRNA-145 to Regulate Kruppel-like Factor 4 and Myocardin Expression in Human Coronary Arterial Smooth Muscle Cells under High Glucose Conditions

MicroRNA (miR)-145 is the most abundant miR in vascular smooth muscle cells (VSMCs). However, the effect of hyperglycemia on the regulation of miR-145 is unknown. We hypothesized that the hyperglycemic condition activates a proinflammatory response that mediates the expression of miR-145 in VSMCs. W...

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Bibliographische Detailangaben
Veröffentlicht in:Mol Med
Hauptverfasser: Shyu, Kou-Gi, Cheng, Wen-Ping, Wang, Bao-Wei
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Feinstein Institute Press 2015
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4656198/
https://ncbi.nlm.nih.gov/pubmed/26181633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/molmed.2015.00041
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