EPA, not DHA, prevents fibrosis in pressure overload-induced heart failure: potential role of free fatty acid receptor 4

Heart failure with preserved ejection fraction (HFpEF) is half of all HF, but standard HF therapies are ineffective. Diastolic dysfunction, often secondary to interstitial fibrosis, is common in HFpEF. Previously, we found that supra-physiologic levels of ω3-PUFAs produced by 12 weeks of ω3-dietary...

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Veröffentlicht in:J Lipid Res
Hauptverfasser: Eclov, Julie A., Qian, Qingwen, Redetzke, Rebecca, Chen, Quanhai, Wu, Steven C., Healy, Chastity L., Ortmeier, Steven B., Harmon, Erin, Shearer, Gregory C., O’Connell, Timothy D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Biochemistry and Molecular Biology 2015
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Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4655986/
https://ncbi.nlm.nih.gov/pubmed/26435012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M062034
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