ω-3 fatty acids prevent pressure overload-induced cardiac fibrosis through activation of cGMP/PKG signaling in cardiac fibroblasts

BACKGROUND: Omega-3 polyunsaturated fatty acids [ω-3 PUFAs, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)] from fish oil ameliorate cardiovascular diseases. However, little is known about the effects of ω-3 PUFAs on cardiac fibrosis, a major cause of diastolic dysfunction and heart fail...

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Main Authors: Chen, Jinghai, Shearer, Gregory C., Chen, Quanhai, Healy, Chastity L., Beyer, April J., Nareddy, Vijaya B., Gerdes, A. Martin, Harris, William S., O’Connell, Timothy D., Wang, Dajun
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3056077/
https://ncbi.nlm.nih.gov/pubmed/21282499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.110.971853
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