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X-ray crystallography over the past decade for novel drug discovery – where are we heading next?

INTRODUCTION: Macromolecular X-ray crystallography has been the primary methodology for determining the three-dimensional structures of proteins, nucleic acids and viruses. Structural information has paved the way for structure-guided drug discovery and laid the foundations for structural bioinforma...

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Detalhes bibliográficos
Publicado no:Expert Opin Drug Discov
Main Authors: Zheng, Heping, Handing, Katarzyna B, Zimmerman, Matthew D, Shabalin, Ivan G, Almo, Steven C, Minor, Wladek
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4655606/
https://ncbi.nlm.nih.gov/pubmed/26177814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1517/17460441.2015.1061991
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