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Metabolic vulnerability of KRAS-driven cancer cells
Interfering with anaplerotic utilization of glutamine (Gln) was recently reported to sensitize KRAS-driven cancer cells to the cytotoxic effects of capecitabine and paclitaxel. This effect was due to bypass of a Gln-dependent G(1) cell cycle checkpoint in these cells. This study highlights therapeut...
Gespeichert in:
| Veröffentlicht in: | Mol Cell Oncol |
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| 1. Verfasser: | |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Taylor & Francis
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4655600/ https://ncbi.nlm.nih.gov/pubmed/26609545 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/23723548.2014.963445 |
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