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High-resolution structures of the M2 channel from influenza A virus reveal dynamic pathways for proton stabilization and transduction
The matrix 2 (M2) protein from influenza A virus is a proton channel that uses His37 as a selectivity filter. Here we report high-resolution (1.10 Å) cryogenic crystallographic structures of the transmembrane domain of M2 at low and high pH. These structures reveal that waters within the pore form h...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4655559/ https://ncbi.nlm.nih.gov/pubmed/26578770 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1518493112 |
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