High-resolution structures of the M2 channel from influenza A virus reveal dynamic pathways for proton stabilization and transduction

The matrix 2 (M2) protein from influenza A virus is a proton channel that uses His37 as a selectivity filter. Here we report high-resolution (1.10 Å) cryogenic crystallographic structures of the transmembrane domain of M2 at low and high pH. These structures reveal that waters within the pore form h...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Proc Natl Acad Sci U S A
Egile Nagusiak: Thomaston, Jessica L., Alfonso-Prieto, Mercedes, Woldeyes, Rahel A., Fraser, James S., Klein, Michael L., Fiorin, Giacomo, DeGrado, William F.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2015
Gaiak:
Biological Sciences
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4655559/
https://ncbi.nlm.nih.gov/pubmed/26578770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1518493112
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