Telomeric repeat-containing RNA (TERRA) constitutes a nucleoprotein component of extracellular inflammatory exosomes

Telomeric repeat-containing RNA (TERRA) has been identified as a telomere-associated regulator of chromosome end protection. Here, we report that TERRA can also be found in extracellular fractions that stimulate innate immune signaling. We identified extracellular forms of TERRA in mouse tumor and e...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Wang, Zhuo, Deng, Zhong, Dahmane, Nadia, Tsai, Kevin, Wang, Pu, Williams, Dewight R., Kossenkov, Andrew V., Showe, Louise C., Zhang, Rugang, Huang, Qihong, Conejo-Garcia, José R., Lieberman, Paul M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2015
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PNAS Plus
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4655533/
https://ncbi.nlm.nih.gov/pubmed/26578789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1505962112
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