The activity of protein phosphatase 5 towards native clients is modulated by the middle- and C-terminal domains of Hsp90

Protein phosphatase 5 is involved in the regulation of kinases and transcription factors. The dephosphorylation activity is modulated by the molecular chaperone Hsp90, which binds to the TPR-domain of protein phosphatase 5. This interaction is dependent on the C-terminal MEEVD motif of Hsp90. We sho...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Haslbeck, Veronika, Eckl, Julia M., Drazic, Adrian, Rutz, Daniel A., Lorenz, Oliver R., Zimmermann, Kerstin, Kriehuber, Thomas, Lindemann, Claudia, Madl, Tobias, Richter, Klaus
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2015
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4655416/
https://ncbi.nlm.nih.gov/pubmed/26593036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep17058
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