Cdc37 (Cell Division Cycle 37) Restricts Hsp90 (Heat Shock Protein 90) Motility by Interaction with N-terminal and Middle Domain Binding Sites

The ATPase-driven dimeric molecular Hsp90 (heat shock protein 90) and its cofactor Cdc37 (cell division cycle 37 protein) are crucial to prevent the cellular depletion of many protein kinases. In complex with Hsp90, Cdc37 is thought to bind an important lid structure in the ATPase domain of Hsp90 an...

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Bibliografiske detaljer
Main Authors: Eckl, Julia M., Rutz, Daniel A., Haslbeck, Veronika, Zierer, Bettina K., Reinstein, Jochen, Richter, Klaus
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2013
Fag:
Cell Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3668759/
https://ncbi.nlm.nih.gov/pubmed/23569206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.439257
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