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CD4(+) T cell tolerance to tissue-restricted self antigens is mediated by antigen-specific regulatory T cells rather than deletion
Deletion of self antigen-specific T cells during thymic development provides protection from autoimmunity. However, it is unclear how efficiently this occurs for tissue-restricted self antigens, or how immune tolerance is maintained for self antigen-specific T cells that routinely escape deletion. H...
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| Publicado en: | Immunity |
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| Autores principales: | , , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2015
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4654997/ https://ncbi.nlm.nih.gov/pubmed/26572061 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2015.10.011 |
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