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Inflammasomes coordinate pyroptosis and natural killer cell cytotoxicity to clear infection by a ubiquitous environmental bacterium

Defective neutrophils in patients with chronic granulomatous disease (CGD) cause susceptibility to extracellular and intracellular infections. As microbes must first be ejected from intracellular niches to expose them to neutrophil attack, we hypothesized that inflammasomes detect certain CGD pathog...

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Detalhes bibliográficos
Publicado no:Immunity
Main Authors: Maltez, Vivien I., Tubbs, Alan L., Cook, Kevin D., Aachoui, Youssef, Falcone, E. Liana, Holland, Steven M., Whitmire, Jason K., Miao, Edward A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4654968/
https://ncbi.nlm.nih.gov/pubmed/26572063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2015.10.010
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