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Matrix-derived inflammatory mediator N-acetyl proline-glycine-proline is neurotoxic and upregulated in brain after ischemic stroke

BACKGROUND: N-acetyl proline-glycine-proline (ac-PGP) is a matrix-derived chemokine produced through the proteolytic destruction of collagen by matrix metalloproteinases (MMPs). While upregulation and activation of MMPs and concomitant degradation of the extracellular matrix are known to be associat...

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Detalhes bibliográficos
Publicado no:J Neuroinflammation
Main Authors: Hill, Jeff W., Nemoto, Edwin M.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4654865/
https://ncbi.nlm.nih.gov/pubmed/26588897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-015-0428-z
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