Cell-mediated fiber recruitment drives extracellular matrix mechanosensing in engineered fibrillar microenvironments

To investigate how cells sense stiffness in settings structurally similar to native extracellular matrices (ECM), we designed a synthetic fibrous material with tunable mechanics and user-defined architecture. In contrast to flat hydrogel surfaces, these fibrous materials recapitulated cell-matrix in...

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Veröffentlicht in:Nat Mater
Hauptverfasser: Baker, Brendon M., Trappmann, Britta, Wang, William Y., Sakar, Mahmut S., Kim, Iris L., Shenoy, Vivek B., Burdick, Jason A., Chen, Christopher S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4654682/
https://ncbi.nlm.nih.gov/pubmed/26461445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmat4444
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