A Cell Culture System for Distinguishing Hepatitis C Viruses with and without Liver Cancer-related Mutations in the Viral Core Gene

BACKGROUND AND AIMS: Although patients infected by genotype-1b hepatitis C virus (HCV) with Q(70) and/or M(91) core gene mutations have an almost five-fold increased risk of developing hepatocellular carcinoma (HCC) and increased insulin resistance, the absence of a suitable experimental system has...

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Pubblicato in:J Hepatol
Autori principali: El-Shamy, Ahmed, Eng, Francis J., Doyle, Erin H., Klepper, Arielle L., Sun, Xiaochen, Sangiovanni, Angelo, Iavarone, Massimo, Colombo, Massimo, Schwartz, Robert E., Hoshida, Yujin, Branch, Andrea D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4654634/
https://ncbi.nlm.nih.gov/pubmed/26220749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2015.07.024
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