miRs-138 and -424 control palmitoylation-dependent CD95-mediated cell death by targeting acyl protein thioesterases 1 and 2 in CLL

Resistance toward CD95-mediated apoptosis is a hallmark of many different malignancies, as it is known from primary chronic lymphocytic leukemia (CLL) cells. Previously, we could show that miR-138 and -424 are downregulated in CLL cells. Here, we identified 2 new target genes, namely acyl protein th...

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Detalhes bibliográficos
Publicado no:Blood
Principais autores: Berg, Valeska, Rusch, Marion, Vartak, Nachiket, Jüngst, Christian, Schauss, Astrid, Waldmann, Herbert, Hedberg, Christian, Pallasch, Christian P., Bastiaens, Philippe I. H., Hallek, Michael, Wendtner, Clemens-Martin, Frenzel, Lukas P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2015
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4654424/
https://ncbi.nlm.nih.gov/pubmed/25670628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-07-586511
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