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Mutagenic consequences of a single G-quadruplex demonstrate mitotic inheritance of DNA replication fork barriers

Faithful DNA replication is vital to prevent disease-causing mutations, chromosomal aberrations and malignant transformation. However, accuracy conflicts with pace and flexibility and cells rely on specialized polymerases and helicases to ensure effective and timely replication of genomes that conta...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Lemmens, Bennie, van Schendel, Robin, Tijsterman, Marcel
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4654259/
https://ncbi.nlm.nih.gov/pubmed/26563448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9909
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