Sex Differences in Plasmacytoid Dendritic Cell Levels of IRF5 Drive Higher IFN-α Production in Women

Increased IFN-α production contributes to the pathogenesis of infectious and autoimmune diseases. Plasmacytoid dendritic cells (pDCs) from females produce more IFN-α upon TLR7 stimulation than pDCs from males, yet the mechanisms underlying this difference remain unclear. In this article, we show tha...

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Udgivet i:J Immunol
Main Authors: Griesbeck, Morgane, Ziegler, Susanne, Laffont, Sophie, Smith, Nikaïa, Chauveau, Lise, Tomezsko, Phillip, Sharei, Armon, Kourjian, Georgio, Porichis, Filippos, Hart, Meghan, Palmer, Christine D., Sirignano, Michael, Beisel, Claudia, Hildebrandt, Heike, Cénac, Claire, Villani, Alexandra-Chloé, Diefenbach, Thomas J., Le Gall, Sylvie, Schwartz, Olivier, Herbeuval, Jean-Philippe, Autran, Brigitte, Guéry, Jean-Charles, Chang, J. Judy, Altfeld, Marcus
Format: Artigo
Sprog:Inglês
Udgivet: AAI 2015
Fag:
Innate Immunity and Inflammation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4654231/
https://ncbi.nlm.nih.gov/pubmed/26519527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1501684
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