Costimulation of IL-2 Production through CD28 Is Dependent on the Size of Its Ligand

Optimal T cell activation typically requires engagement of both the TCR and costimulatory receptors, such as CD28. Engagement of CD28 leads to tyrosine phosphorylation of its cytoplasmic region and recruitment of cytoplasmic signaling proteins. Although the exact mechanism of CD28 signal transductio...

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Dades bibliogràfiques
Publicat a:J Immunol
Autors principals: Lim, Hong-Sheng, Cordoba, Shaun-Paul, Dushek, Omer, Goyette, Jesse, Taylor, Alison, Rudd, Christopher E., van der Merwe, P. Anton
Format: Artigo
Idioma:Inglês
Publicat: AAI 2015
Matèries:
Molecular and Structural Immunology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4654228/
https://ncbi.nlm.nih.gov/pubmed/26500347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1500707
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