Costimulation of IL-2 Production through CD28 Is Dependent on the Size of Its Ligand

Optimal T cell activation typically requires engagement of both the TCR and costimulatory receptors, such as CD28. Engagement of CD28 leads to tyrosine phosphorylation of its cytoplasmic region and recruitment of cytoplasmic signaling proteins. Although the exact mechanism of CD28 signal transductio...

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Dettagli Bibliografici
Pubblicato in:J Immunol
Autori principali: Lim, Hong-Sheng, Cordoba, Shaun-Paul, Dushek, Omer, Goyette, Jesse, Taylor, Alison, Rudd, Christopher E., van der Merwe, P. Anton
Natura: Artigo
Lingua:Inglês
Pubblicazione: AAI 2015
Soggetti:
Molecular and Structural Immunology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4654228/
https://ncbi.nlm.nih.gov/pubmed/26500347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1500707
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