Suppression of the GTPase-activating protein RGS10 increases Rheb-GTP and mTOR signaling in ovarian cancer cells

The regulator of G protein signaling 10 (RGS10) protein is a GTPase activating protein that accelerates the hydrolysis of GTP and therefore canonically inactivates G proteins, ultimately terminating signaling. Rheb is a small GTPase protein that shuttles between its GDP- and GTP-bound forms to activ...

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Udgivet i:Cancer Lett
Main Authors: Altman, Molly K., Alshamrani, Ali A., Jia, Wei, Nguyen, Ha, Fambrough, Jada M., Tran, Sterling K., Patel, Mihir, Hoseinzadeh, Pooya, Beedle, Aaron M., Murph, Mandi M.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4654121/
https://ncbi.nlm.nih.gov/pubmed/26319900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2015.08.012
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