Characterization of RA839, a Noncovalent Small Molecule Binder to Keap1 and Selective Activator of Nrf2 Signaling

The activation of the transcription factor NF-E2-related factor 2 (Nrf2) maintains cellular homeostasis in response to oxidative stress by the regulation of multiple cytoprotective genes. Without stressors, the activity of Nrf2 is inhibited by its interaction with the Keap1 (kelch-like ECH-associate...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Winkel, Angelika F., Engel, Christian K., Margerie, Daniel, Kannt, Aimo, Szillat, Hauke, Glombik, Heiner, Kallus, Christopher, Ruf, Sven, Güssregen, Stefan, Riedel, Jens, Herling, Andreas W., von Knethen, Andreas, Weigert, Andreas, Brüne, Bernhard, Schmoll, Dieter
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2015
Subjects:
Gene Regulation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4653701/
https://ncbi.nlm.nih.gov/pubmed/26459563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.678136
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