Competitive Inhibition of the Endoplasmic Reticulum Signal Peptidase by Non-cleavable Mutant Preprotein Cargos

Upon translocation across the endoplasmic reticulum (ER) membrane, secretory proteins are proteolytically processed to remove their signal peptide by signal peptidase (SPase). This process is critical for subsequent folding, intracellular trafficking, and maturation of secretory proteins. Prokaryoti...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Cui, Jingqiu, Chen, Wei, Sun, Jinhong, Guo, Huan, Madley, Rachel, Xiong, Yi, Pan, Xingyi, Wang, Hongliang, Tai, Andrew W., Weiss, Michael A., Arvan, Peter, Liu, Ming
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2015
Soggetti:
Cell Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4653672/
https://ncbi.nlm.nih.gov/pubmed/26446786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.692350
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi