Competitive Inhibition of the Endoplasmic Reticulum Signal Peptidase by Non-cleavable Mutant Preprotein Cargos

Upon translocation across the endoplasmic reticulum (ER) membrane, secretory proteins are proteolytically processed to remove their signal peptide by signal peptidase (SPase). This process is critical for subsequent folding, intracellular trafficking, and maturation of secretory proteins. Prokaryoti...

詳細記述

保存先:
書誌詳細
出版年:J Biol Chem
主要な著者: Cui, Jingqiu, Chen, Wei, Sun, Jinhong, Guo, Huan, Madley, Rachel, Xiong, Yi, Pan, Xingyi, Wang, Hongliang, Tai, Andrew W., Weiss, Michael A., Arvan, Peter, Liu, Ming
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2015
主題:
Cell Biology
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4653672/
https://ncbi.nlm.nih.gov/pubmed/26446786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.692350
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