Competitive Inhibition of the Endoplasmic Reticulum Signal Peptidase by Non-cleavable Mutant Preprotein Cargos

Upon translocation across the endoplasmic reticulum (ER) membrane, secretory proteins are proteolytically processed to remove their signal peptide by signal peptidase (SPase). This process is critical for subsequent folding, intracellular trafficking, and maturation of secretory proteins. Prokaryoti...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Biol Chem
Egile Nagusiak: Cui, Jingqiu, Chen, Wei, Sun, Jinhong, Guo, Huan, Madley, Rachel, Xiong, Yi, Pan, Xingyi, Wang, Hongliang, Tai, Andrew W., Weiss, Michael A., Arvan, Peter, Liu, Ming
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2015
Gaiak:
Cell Biology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4653672/
https://ncbi.nlm.nih.gov/pubmed/26446786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.692350
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