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Evolution of chemical diversity by coordinated gene swaps in type II polyketide gene clusters
Natural product biosynthetic pathways generate molecules of enormous structural complexity and exquisitely tuned biological activities. Studies of natural products have led to the discovery of many pharmaceutical agents, particularly antibiotics. Attempts to harness the catalytic prowess of biosynth...
Guardat en:
| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4653136/ https://ncbi.nlm.nih.gov/pubmed/26499248 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1511688112 |
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