Skeletal muscle mitochondrial uncoupling prevents diabetes but not obesity in NZO mice, a model for polygenic diabesity

Induction of skeletal muscle (SM) mitochondrial stress by expression of uncoupling protein 1 (UCP1) in mice results in a healthy metabolic phenotype associated with increased secretion of FGF21 from SM. Here, we investigated whether SM mitochondrial uncoupling can compensate obesity and insulin resi...

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Detalhes bibliográficos
Publicado no:Genes Nutr
Main Authors: Voigt, Anja, Katterle, Yvonne, Kahle, Melanie, Kluge, Reinhart, Schürmann, Annette, Joost, Hans-Georg, Klaus, Susanne
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4653120/
https://ncbi.nlm.nih.gov/pubmed/26584809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12263-015-0507-x
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