Hyperglycemia stimulates p62/PKCζ interaction, which mediates NF-κB activation, increased Nox4 expression, and inflammatory cytokine activation in vascular smooth muscle

Hyperglycemia leads to vascular smooth muscle cell (VSMC) dedifferentiation and enhances responses to IGF-I. Prior studies showed that hyperglycemia stimulated NADPH oxidase 4 (Nox4) synthesis, and IGF-I facilitated its recruitment to a signaling complex where it oxidized src, leading to AKT and MAP...

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Vydáno v:FASEB J
Hlavní autoři: Xi, Gang, Shen, Xinchun, Wai, Christine, Vilas, Caroline K., Clemmons, David R.
Médium: Artigo
Jazyk:Inglês
Vydáno: Federation of American Societies for Experimental Biology 2015
Témata:
Research Communication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4653052/
https://ncbi.nlm.nih.gov/pubmed/26231202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.15-275453
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