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Confirmation of the cellular targets of benomyl and rapamycin using next- generation sequencing of resistant mutants in S. cerevisiae

Investigating the mechanisms of action (MOAs) of bioactive compounds and the deconvolution of their cellular targets is an important and challenging undertaking. Drug resistance in model organisms such as S. cerevisiae has long been a means for discovering drug targets and MOAs. Strains are selected...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Mol Biosyst
Hauptverfasser: Wride, Dustin A., Pourmand, Nader, Bray, Walter M., Kosarchuk, Jacob J., Nisam, Sean C., Quan, Tiffani K., Berkeley, Ray F., Katzman, Sol, Hartzog, Grant A., Dobkin, Carlos E., Lokey, R. Scott
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4653042/
https://ncbi.nlm.nih.gov/pubmed/25257345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c4mb00146j
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