Confirmation of the cellular targets of benomyl and rapamycin using next- generation sequencing of resistant mutants in S. cerevisiae

Investigating the mechanisms of action (MOAs) of bioactive compounds and the deconvolution of their cellular targets is an important and challenging undertaking. Drug resistance in model organisms such as S. cerevisiae has long been a means for discovering drug targets and MOAs. Strains are selected...

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Detalhes bibliográficos
Publicado no:Mol Biosyst
Main Authors: Wride, Dustin A., Pourmand, Nader, Bray, Walter M., Kosarchuk, Jacob J., Nisam, Sean C., Quan, Tiffani K., Berkeley, Ray F., Katzman, Sol, Hartzog, Grant A., Dobkin, Carlos E., Lokey, R. Scott
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4653042/
https://ncbi.nlm.nih.gov/pubmed/25257345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c4mb00146j
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