A small-molecule inhibitor suppresses the tumor-associated mitochondrial NAD(P)(+)-dependent malic enzyme (ME2) and induces cellular senescence

Here, we found a natural compound, embonic acid (EA), that can specifically inhibit the enzymatic activity of mitochondrial NAD(P)(+)-dependent malic enzyme (m-NAD(P)-ME, ME2) either in vitro or in vivo. The in vitro IC(50) value of EA for m-NAD(P)-ME was 1.4 ± 0.4 μM. Mutagenesis and binding studie...

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Опубликовано в: :Oncotarget
Главные авторы: Hsieh, Ju-Yi, Li, Shao-Yu, Tsai, Wen-Chen, Liu, Jyung-Hurng, Lin, Chih-Li, Liu, Guang-Yaw, Hung, Hui-Chih
Формат: Artigo
Язык:Inglês
Опубликовано: Impact Journals LLC 2015
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Research Paper
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4652989/
https://ncbi.nlm.nih.gov/pubmed/26008970
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