How data analysis affects power, reproducibility and biological insight of RNA-seq studies in complex datasets

The sequencing of the full transcriptome (RNA-seq) has become the preferred choice for the measurement of genome-wide gene expression. Despite its widespread use, challenges remain in RNA-seq data analysis. One often-overlooked aspect is normalization. Despite the fact that a variety of factors or ‘...

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Détails bibliographiques
Publié dans:Nucleic Acids Res
Auteurs principaux: Peixoto, Lucia, Risso, Davide, Poplawski, Shane G., Wimmer, Mathieu E., Speed, Terence P., Wood, Marcelo A., Abel, Ted
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2015
Sujets:
Survey and Summary
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4652761/
https://ncbi.nlm.nih.gov/pubmed/26202970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv736
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