Phospho1 deficiency transiently modifies bone architecture yet produces consistent modification in osteocyte differentiation and vascular porosity with ageing

PHOSPHO1 is one of principal proteins involved in initiating bone matrix mineralisation. Recent studies have found that Phospho1 KO mice (Phospho1-R74X) display multiple skeletal abnormalities with spontaneous fractures, bowed long bones, osteomalacia and scoliosis. These analyses have however been...

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Dettagli Bibliografici
Pubblicato in:Bone
Autori principali: Javaheri, B., Carriero, A., Staines, K.A., Chang, Y.-M., Houston, D.A., Oldknow, K.J., Millan, J.L., Kazeruni, Bassir N., Salmon, P., Shefelbine, S., Farquharson, C., Pitsillides, A.A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier Science 2015
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Original Full Length Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4652607/
https://ncbi.nlm.nih.gov/pubmed/26232374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2015.07.035
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