PACAP intraperitoneal treatment suppresses appetite and food intake via PAC1 receptor in mice by inhibiting ghrelin and increasing GLP-1 and leptin

Pituitary adenylate cyclase-activating peptide (PACAP) is expressed within the gastroenteric system, where it has profound physiological effects. PACAP was shown to regulate food intake and thermogenesis centrally; however, PACAP peripheral regulation of appetite and feeding behavior is unknown. The...

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Vydáno v:Am J Physiol Gastrointest Liver Physiol
Hlavní autoři: Vu, John P., Goyal, Deepinder, Luong, Leon, Oh, Suwan, Sandhu, Ravneet, Norris, Joshua, Parsons, William, Pisegna, Joseph R., Germano, Patrizia M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2015
Témata:
Hormones, Neurotransmitters, Growth Factors, Receptors, and Signaling
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4652141/
https://ncbi.nlm.nih.gov/pubmed/26336928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00190.2015
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