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Splicing regulation in spinal muscular atrophy by a RNA structure formed by long distance interactions
Humans carry two copies of Survival Motor Neuron gene: SMN1 and SMN2. Loss of SMN1 coupled with skipping of SMN2 exon 7 causes spinal muscular atrophy (SMA), a leading genetic disease associated with infant mortality. Our discovery of intronic splicing silencer N1 (ISS-N1) is a promising target, cur...
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| Yayımlandı: | Ann N Y Acad Sci |
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| Asıl Yazarlar: | , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2015
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4651915/ https://ncbi.nlm.nih.gov/pubmed/25727246 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/nyas.12727 |
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