In Oesophageal Squamous Cells, Nitric Oxide Causes S-Nitrosylation of Akt and Blocks SOX2 (Sex Determining Region Y-Box 2) Expression

OBJECTIVE: Barrett’s metaplasia might develop if GORD causes oesophageal squamous cells to convert into columnar cells. Acid and bile exposures upregulate columnar differentiation genes like CDX2 in oesophageal squamous cells, but it is not known if such exposures downregulate squamous differentiati...

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Bibliografische gegevens
Gepubliceerd in:Gut
Hoofdauteurs: Asanuma, Kiyotaka, Huo, Xiaofang, Agoston, Agoston, Zhang, Xi, Yu, Chunhua, Cheng, Edaire, Zhang, Qiuyang, Dunbar, Kerry B., Pham, Thai H., Wang, David H., Iijima, Katsunori, Shimosegawa, Tooru, Odze, Robert D., Spechler, Stuart J., Souza, Rhonda F.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4651671/
https://ncbi.nlm.nih.gov/pubmed/25986942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2015-309272
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