The Expression of TALEN before Fertilization Provides a Rapid Knock-Out Phenotype in Xenopus laevis Founder Embryos

Recent advances in genome editing using programmable nucleases have revolutionized gene targeting in various organisms. Successful gene knock-out has been shown in Xenopus, a widely used model organism, although a system enabling less mosaic knock-out in founder embryos (F0) needs to be explored in...

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Publicado en:PLoS One
Autores principales: Miyamoto, Kei, Suzuki, Ken-ichi T., Suzuki, Miyuki, Sakane, Yuto, Sakuma, Tetsushi, Herberg, Sarah, Simeone, Angela, Simpson, David, Jullien, Jerome, Yamamoto, Takashi, Gurdon, J. B.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4651567/
https://ncbi.nlm.nih.gov/pubmed/26580070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0142946
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