Aspirin, Ibuprofen, and the Risk for Colorectal Cancer in Lynch Syndrome

BACKGROUND: Inheritance of a germline mutation in one of the DNA mismatch repair (MMR) genes MLH1, MSH2, MSH6, and PMS2 causes a high risk of colorectal and other cancers (Lynch Syndrome). Use of aspirin has been shown to be associated with a reduced risk of colorectal cancer for the general populat...

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Udgivet i:J Natl Cancer Inst
Main Authors: Ait Ouakrim, Driss, Dashti, Seyedeh Ghazaleh, Chau, Rowena, Buchanan, Daniel D., Clendenning, Mark, Rosty, Christophe, Winship, Ingrid M., Young, Joanne P., Giles, Graham G., Leggett, Barbara, Macrae, Finlay A., Ahnen, Dennis J., Casey, Graham, Gallinger, Steven, Haile, Robert W., Le Marchand, Loïc, Thibodeau, Stephen N., Lindor, Noralane M., Newcomb, Polly A., Potter, John D., Baron, John A., Hopper, John L., Jenkins, Mark A., Win, Aung Ko
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4651105/
https://ncbi.nlm.nih.gov/pubmed/26109217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/djv170
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