Aspirin, Ibuprofen, and the Risk for Colorectal Cancer in Lynch Syndrome

BACKGROUND: Inheritance of a germline mutation in one of the DNA mismatch repair (MMR) genes MLH1, MSH2, MSH6, and PMS2 causes a high risk of colorectal and other cancers (Lynch Syndrome). Use of aspirin has been shown to be associated with a reduced risk of colorectal cancer for the general populat...

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Vydáno v:J Natl Cancer Inst
Hlavní autoři: Ait Ouakrim, Driss, Dashti, Seyedeh Ghazaleh, Chau, Rowena, Buchanan, Daniel D., Clendenning, Mark, Rosty, Christophe, Winship, Ingrid M., Young, Joanne P., Giles, Graham G., Leggett, Barbara, Macrae, Finlay A., Ahnen, Dennis J., Casey, Graham, Gallinger, Steven, Haile, Robert W., Le Marchand, Loïc, Thibodeau, Stephen N., Lindor, Noralane M., Newcomb, Polly A., Potter, John D., Baron, John A., Hopper, John L., Jenkins, Mark A., Win, Aung Ko
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4651105/
https://ncbi.nlm.nih.gov/pubmed/26109217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/djv170
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