Exosomes derived from alcohol-treated hepatocytes horizontally transfer liver specific miRNA-122 and sensitize monocytes to LPS

Hepatocyte damage and inflammation in monocytes/macrophages are central to the pathogenesis of alcoholic hepatitis (AH). MicroRNAs (miRNAs) regulate all of these processes. MiRNA-122 is abundantly expressed in hepatocytes while monocytes/macrophages have low levels. The role of exosomes in AH and po...

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Vydáno v:Sci Rep
Hlavní autoři: Momen-Heravi, Fatemeh, Bala, Shashi, Kodys, Karen, Szabo, Gyongyi
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4650752/
https://ncbi.nlm.nih.gov/pubmed/25973575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep09991
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