Sigma-1 receptor deficiency reduces MPTP-induced parkinsonism and death of dopaminergic neurons

Sigma-1 receptor (σ(1)R) has been reported to be decreased in nigrostriatal motor system of Parkinson's disease patients. Using heterozygous and homozygous σ(1)R knockout (σ(1)R(+/−) and σ(1)R(−/−)) mice, we investigated the influence of σ(1)R deficiency on 1-methyl-4-phenyl-1,2,3,6-tetrahydrop...

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Udgivet i:Cell Death Dis
Main Authors: Hong, J, Sha, S, Zhou, L, Wang, C, Yin, J, Chen, L
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2015
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4650739/
https://ncbi.nlm.nih.gov/pubmed/26203861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2015.194
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