Wnt addiction of genetically defined cancers reversed by PORCN inhibition

Enhanced sensitivity to Wnts is an emerging hallmark of a subset of cancers, defined in part by mutations regulating the abundance of their receptors. Whether these mutations identify a clinical opportunity is an important question. Inhibition of Wnt secretion by blocking an essential post-translati...

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Publicado en:Oncogene
Autores principales: Madan, B, Ke, Z, Harmston, N, Ho, S Y, Frois, A O, Alam, J, Jeyaraj, D A, Pendharkar, V, Ghosh, K, Virshup, I H, Manoharan, V, Ong, E H Q, Sangthongpitag, K, Hill, J, Petretto, E, Keller, T H, Lee, M A, Matter, A, Virshup, D M
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4650263/
https://ncbi.nlm.nih.gov/pubmed/26257057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2015.280
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